Insulin Resistance and Metabolic Syndrome

Insulin resistance lies at the core of metabolic syndrome, a cluster of metabolic abnormalities including central obesity, dyslipidemia, hypertension, and impaired glucose metabolism. Insulin resistance disrupts cellular signaling pathways, leading to metabolic dysregulation and increased cardiovascular risk. Mechanisms linking insulin resistance to metabolic syndrome involve adipose tissue dysfunction, chronic low-grade inflammation, and mitochondrial dysfunction. Lifestyle interventions targeting insulin sensitivity through dietary modifications and exercise can mitigate metabolic syndrome components and reduce cardiovascular risk. Pharmacotherapeutic approaches also aim to improve insulin sensitivity and address individual components of metabolic syndrome, emphasizing personalized management strategies in high-risk individuals.

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