19^th World Congress on Endocrinology & Diabetes November 22-23, 2023 Amsterdam, Netherlands

The endocrine system is a network of glands that produce and release hormones directly into blood which help in controlling many important body functions. The endocrine system influences heartbeat, growth of bones and tissue, even the ability to make a baby. It plays a role on development of diabetes, thyroid disease, growth disorders, sexual dysfunction, and a host of other hormone-related disorders.

Endocrine cancer is cancer that begins in any of the endocrine glands. The most common type of endocrine cancer is thyroid cancer, which begins in the thyroid gland. Endocrine cancer is a complex disease which is not defined by defined by location or stage. Cancer in each patient is different, behaving differently in the bodies.

Reproductive endocrinology may be a medicine for infertility, menopause, and other issues with reproductive hormones. Reproductive endocrinologists are OB/GYN (obstetrics and gynecology) doctors with special training to assist both men and ladies with problems associated with reproductive hormones. Sometimes, this specialty is named reproductive endocrinology and infertility because much of their work focuses on helping women to become pregnant and carry a baby to term.

· Infertility

· Fertility preservation

· Frequent miscarriages

· Endometriosis

· Menstrual problems

· Menopause

· Sexual development

The tracks discusses concerning the dire increase within the prevalence of various hormone-related medical conditions like diabetes, hypogonadism, hypothyroidism and hyperthyroidism. Interventions in medicine create an enormous impact on lifespan of patients with endocrine diseases. This endocrinology conference discusses the role vie by each medical and surgical interventions in practice of endocrinology. Endocrinology is branch of medication wherever treatment is as near ideal as doable. For individuals with endocrine deficiencies, medical intervention in sort of replacement with hormones generated by recombinant technologies may be a perfectly natural treatment. Hormone excess is also being evaluated and treated with passing precise surgical interventions with minimal morbidity. The global endocrinology market is poised to grow regularly at a CAGR of more than 6% over the forecast period, as per Technavio. The Global Endocrine Testing Market will grow strong during the forecast period 2017 to 2025. According to several analyses, nearly 415 million individuals were affected by diabetes in 2015 and this number is very likely to touch 642 million by 2040.

The Endocrine system controls the stream of information among cells and tissues, represented by complex managerial parts. Hormones apply in all cases impacts on various metabolic methods which ensure regulatory, change genic and integrative limit. Signs and indications of endocrine issue navigate the complete clinical range. The Endocrine system is a system of organs that create and discharge hormones that assistance controls numerous imperative body capacities, including the body's capacity to change calories into energy that forces cells and organs. The Endocrine system impacts how your heart beats, how your bones and tissues develop, even your capacity to make a child. It assumes a key half in despite whether or not you produce diabetes, thyroid illness, development issue, sexual brokenness, and a large group of other hormone-related disorders. Endocrine disease that outcomes once an organ delivers overly or deficient of an endocrine hormone, called a hormone imbalance. Endocrine disease is because of the improvement of injuries, (for example, knobs or tumours) in the endocrine system, which might influence hormone levels. Endocrine disorders may well be symptomless or sufficiently mild to not need treatment. Surgery or radiation treatment might be utilized. Regularly, finding and treatment of the hidden reason for the endocrine issue can resolve the symptoms.

It is estimated that over 12,000 Americans are diagnosed with an endocrine tumor every year. Over 1,500 people in the United States are diagnosed with Merkel cell skin cancer each year. Most of the people diagnosed with the disease are over age 50, and 90% of cases occur in white people. The 5-year survival rate of people with Merkel cell cancer is about 60%. MEN1 (Multiple endocrine neoplasia type 1) is a hereditary condition associated with tumors of the endocrine glands. MEN1 was originally known as Wermer syndrome. It is estimated that about 1 in 30,000 people has MEN1. According to studies, about 10% of people with MEN1 do not have a family history of the condition; they have a de novo (new) mutation in the MEN1 gene.

Insulin resistance contributes to the pathophysiology of diabetes. It is a hallmark of obesity, metabolic syndrome and other cardiovascular diseases. Direct and indirect methods of varying complexity are currently employed for these purposes. Endocrine disorders involve the bodies over production or under production of certain hormones while the metabolic disorders affect the body’s ability to process certain nutrients and vitamins. Endocrine disorders include several diseases like hypothyroidism, congenital adrenal hyperplasia, diseases of the parathyroid gland, diabetes mellitus, diseases of the adrenal glands (including Cushing’s syndrome and Addison’s disease), and ovarian dysfunction among others. Examples of metabolic disorders include cystic fibrosis, phenylketonuria (PKU), hyperlipidemia, gout, and rickets.

Diabetes is also a typical chronic sickness that imposes right sensible demands on the individual tending system. Individuals with genetic disorder have subsequent rate of disorder than those whereas not diabetes and are at increased risk for kidney disease, lower limb amputation and visual defect. Novel remedial targets accessible for polygenic disease incorporates Incretion based totally treatments, oral useful operators like secretagogues, cell recovery and enlargement and foundational organism treatments. Undeveloped Embryonic cell and fetal antecedent cell transplantation treatments are the significant undifferentiated cell treatments accessible for Diabetes. Aside from the on top of, different computational methodologies in Diabetes administration control have been presented as of late which are assuming an imperative part in recognizable proof of qualities delivery regarding diabetes serving to in Early Detection of polygenic disease. These procedures are likewise valuable in concentrating on the compound diagnostician of polygenic disorder revealing fully completely different treatment prospects and model development forms for survival expectation. The global diabetes research market is projected to reach USD $10.58 billion by 2022 from an estimated USD $8.35 billion in 2017, at a CAGR of 4.8% during the forecast period.

Diabetes mellitus type 1 (otherwise called type-1 diabetes) is a type of diabetes mellitus that outcomes from the immune system annihilation of the insulin-delivering beta cells in the pancreas. The ensuing absence of hypoglycaemic agent prompts expanded aldohexose within the blood and pee. The established manifestations are regular pee, expanded thirst, expanded yearning, and weight reduction. The reason for diabetes type one is obscure. Type-1 diabetes is recognized from kind two from antibody testing. The C-peptide test, which measures endogenous insulin generation, can likewise be utilized. Organization of insulin is fundamental for survival. Insulin treatment must be proceeded with uncertainly and commonly does not disable ordinary every day exercises. Individuals are usually ready to freely take care of their diabetes; be that because it could, for a few these will challenge. Untreated, diabetes can bring about numerous confusions. Intense confusions incorporate diabetic ketoacidosis and non-ketotic hyperosmolar trance like state. Genuine end of the day complexities known with high glucose incorporate coronary unwellness, stroke, kidney disappointment, foot ulcers and harm to the eyes. Moreover, confusions could emerge from low aldohexose caused by extortionate hypoglycemic agent treatment. Diabetes mellitus type 1 represents around five-hitter and 100% of all diabetes cases.

Type-2 diabetes may be a long-term metabolic turmoil that's pictured by high aldohexose, insulin resistance, and relative absence of insulin. Basic aspect effects incorporate expanded thirst, incessant pee, and unexplained weight reduction. Indications could likewise incorporate swollen desire, feeling tired, and bruises that don't recuperate. Regularly indications go ahead gradually. Long haul complexities from high aldohexose incorporate coronary malady, strokes, diabetic retinopathy which can bring about visual impairment, kidney disappointment, and poor blood stream in the appendages which may prompt removals. The sudden onset of hyperosmolar hyperglycaemic state may happen; in any case, diabetic ketoacidosis is unprecedented. Type 2 diabetes is mostly preventable by staying a typical weight, practicing consistently, and eating legitimately. Treatment includes activity and dietary changes. In the event that aldohexose levels aren't sufficiently brought down, the medicine metformin is regularly suggested. Numerous individuals may in the end likewise require insulin infusions. In that on insulin, routinely check glucose levels is exhorted, in any case this may not be required in those taking pills. Bariatric surgery of times enhances diabetes within the people UN agency ar stout. Diabetes mellitus may be a devastating and sophisticated metabolic malady, expected to affect over 500 million people worldwide by the year 2030; up from 350 million in 2010. Approximately 95% of patients suffer from type 2 diabetes, and its prevalence is expected to increase in the future.

The incidence rate of diabetes is exceptionally high across the world, fueled by reducing physical activities and unhealthy diet. Consistent with IMARC’s report, compared to Type-1 diabetes, Type-2 diabetes represents the more prevalent type, accounting for the bulk of all diagnosed diabetes cases. Urban areas dominate rural areas within the number of diabetes patients and females presently account for the bulk of the entire diabetes patients. Despite the overall down climate of the economy and healthcare, there has been great progress within the advancement of diabetes knowledge, treatment and prevention in recent years. This progress continues of a day to day, with scientific advances being announced at an exponential rate. New therapeutic products are being introduced regularly and therefore the pipeline is now filled with new diabetes therapeutics in development. Never before, within the history of drugs, has the outlook for diabetes treatment and prevention looked so promising. The diabetes drugs segment dominated the endocrinology drugs market and accounted for quite 86% of the market share during 2015. At an annual rate of growth (CAGR) of 4.4%, from 2016 to 2021, World diabetes market projected to succeed in $155 billion by 2021 from $125 billion.

Diabetic nephropathy may be a sort of progressive renal disorder which will occur in people that have diabetes. It affects people with type 1 and type 2 diabetes, and risk increases with the duration of the disease and other risk factors like high vital sign and a case history of renal disorder.

Over 40 percent of cases of renal failure are caused by diabetes, and it’s estimated that approximately 180,000 people live with renal failure caused by complications of diabetes. Diabetes is additionally the foremost common Trusted Source explanation for end-stage renal disease (ESRD). ESRD is that the fifth and end of diabetic nephropathy. Diabetic nephropathy progresses slowly. With early treatment, you'll slow or maybe stop the progression of the disease. Not everyone who develops diabetic nephropathy will reach renal failure or ESRD, and having diabetes doesn't mean you'll develop diabetic nephropathy.

Diabetic retinopathy is a diabetes complication that has its effects on the eyes. It is caused by damage to the blood vessels of the light-sensitive tissue at the rear of the attention (retina). At first, diabetic retinopathy may not cause any symptoms or only mild vision problems. After that, it can cause blindness.

This condition can develop in anyone who is having type 1 or type-2 diabetes. The longer a person has got diabetes and therefore the less controlled his blood glucose is, the more likely he is able to develop this eye complication.

· Early diabetic retinopathy

· Advanced diabetic retinopathy

Stem cells use in islet cell transplants to cure type-1 diabetes, stem cell replacement should be more than just an instance of swapping insulin-delivering cells from a healthy pancreas with those annihilated by diabetes in a diabetic patient. It is conceivable to treat Type-1 diabetes by transplanting confined islet cells, containing beta cells or even an entire pancreas into the patient from a contributor. Transplants will empower the body to recover management of aldohexose levels therefore administrating hypoglycaemic agent is rarely once more needed. Pancreatic stem cell islets, additionally called islets of Langerhans, are modest groups of cells scattered all through the pancreas. Pancreatic islets contain a few types of cells, including beta cells that create the hormone insulin. Insulin permits cells at some stage in the body to retain aldohexose from the circulation system and utilize it for vitality. The global stem cell market is expected to reach USD $15.63 billion by 2025, growing at a CAGR of 9.2%, according to a new report by Grand View Research, Inc. Augmentation in analysis studies that aim at broadening the utility scope of associated merchandise is anticipated to drive the market growth. These analysis comes have opened the chance of implementation of many clinical applications of those cells, thereby impacting disease-modifying treatments.

Diabetes is additionally a typical chronic sickness that imposes right sensible demands on the individual tending system. Individuals with genetic disease have subsequent rate of disorder than those whereas not diabetes and are at increased risk for renal disorder, lower limb amputation and visual impairment. Novel remedial targets accessible for polygenic disorder incorporates Incretion based totally treatments, oral useful operators like secretagogues, cell recovery and enlargement and foundational organism treatments. Undeveloped formative cell and fetal antecedent cell transplantation treatments are the many undifferentiated cell treatments accessible for Diabetes. apart from the on top of, different computational methodologies in Diabetes administration control are presented as lately which are assuming an important part in recognizable proof of qualities delivery regarding diabetes serving to in Early Detection of polygenic disorder. These procedures are likewise valuable in concentrating on the compound diagnostician of polygenic disease revealing fully completely different treatment prospects and model development forms for survival expectation. The worldwide diabetes research market is projected to succeed in USD 10.58 billion by 2022 from an estimated USD 8.35 billion in 2017, at a CAGR of 4.8% during the forecast period.

Nutrition, diet and physical activity are important parts of a healthy lifestyle when you have diabetes. To manage your blood glucose, food, physical activity and diabetes medicine should be balanced. The type of food, quantity, time is all important in keeping the blood glucose level in the range. A diabetes diet is based on eating three meals a day at regular timings. This helps a body to use the insulin in a better way till it produces or gets through a medication. The diet should include healthy carbohydrates, fiber-rich foods, heart-healthy fish, and good fats

Thyroid disorders affect the thyroid gland, a butterfly-shaped gland within the front of the neck. Different types of thyroid disorders affect either its structure or function. The thyroid uses iodine to supply vital hormones. Thyroxine, also referred to as T4, is that the primary hormone produced by the gland. After delivery via the bloodstream to the body's tissues, alittle portion of the T4 released from the gland is converted to triiodothyronine (T3), which is that the most active hormone. The function of the thyroid gland is regulated by a feedback mechanism involving the brain. When hormone levels are low, the hypothalamus within the brain produces a hormone referred to as thyrotropin releasing hormone (TRH) that causes the pituitary to release thyroid stimulating hormone (TSH). TSH stimulates the thyroid to release more T4. Since the thyroid gland is controlled by the pituitary and hypothalamus, disorders of those tissues also can affect thyroid function and cause thyroid problems.

· Goiter

· Hyperthyroidism

· Hypothyroidism

· Thyroid cancer

· Thyroid nodules

·         Thyroiditis

Thyroid issues are not uncommon in youngsters, but rather they are not as regular as guardians. Hyperthyroidism and hyperactive thyroid organ is seen just the once in a while in new-borns. This condition is alluded to as neonatal hyperthyroidism. Although thyroid ailment happens less much of the time in kids than in grown-ups, the signs and indications can be comparable. In any case, there are a couple of essential contrasts that should be conveyed to light. Inborn hypothyroidism is a confusion that influences New-born children during childbirth, and happens in around 1 in 4000 live-conceived babies. It is delineated by the loss of thyroid capability, because of the thyroid organ neglecting to grow regularly. At times, the organ is totally absent. Around 10% of cases are brought on by a catalyst deformity prompting inadequate hormones generation, iodine lack and a cerebrum pituitary organ variation from the norm. On the off chance that the determination is postponed, and quick treatment is not given, innate hypothyroidism can prompt development and formative imperfections, and serious mental impediment (cretinism).

The global thyroid disorders treatment market is probably going to exhibit a 3.1% CAGR between 2015 and 2023. The market is expected to be worth US $2,414.6 mn by the end 2023 from a valuation of US $1,806.2 mn in 2014.

Obesity is a condition in which a person has excess body fat. Obesity can increase a person's risk of diseases and health problems, including high blood pressure, diabetes and heart disease. It is a complex problem and a major public health concern, both in the United States and worldwide. Obesity is most commonly caused by a combination of excessive food intake, lack of physical activity, and genetic susceptibility.  A few cases are caused primarily by genes, endocrine disorders, medications, or mental disorder. The view that obese people eat little yet gain weight due to a slow metabolism is not medically supported. On average, obese people have greater energy expenditure than their normal counterparts due to the energy required to maintain an increased body mass.

A metabolic disorder occurs when the metabolism process fails and causes the body to have either too much or too little of the essential substances needed to stay healthy. Metabolic disorders can take many forms a missing enzyme or vitamin that’s necessary for an important chemical reaction, abnormal chemical reactions that hinder metabolic processes and disease in the liver, pancreas, endocrine glands, or other organs involved in metabolism. Metabolic disorders can be present at birth, and many can be identified by routine screening. If a metabolic disorder is not identified early, then it may be diagnosed later in life, when symptoms appear. Specific blood and DNA tests can be done to diagnose genetic metabolic disorders. The gut microbiota, which is a population of microorganisms that live in the human digestive system, also has an important part in metabolism and generally has a positive function for its host.

· Classification of body fat and fat distribution

· Diagnostic criteria of metabolic syndrome

· Aetiology

· Pathophysiology

· Medical management

· Surgical management

· Prevention

Herbal supplements and remedies are used for the treatment of diabetes and hormonal problems such as estrogen and progesterone levels and treatment for menopausal hormone imbalance, etc. These include Capsaicin cream, a topical ointment made with cayenne, has been reported by some patients to help lower pain in the hands and feet from diabetic neuropathy.  Evening primrose oil is thought to help diabetic nerve pain. Alternative treatments include Acupuncture, Natural Dietary Supplements, and Plant Foods.

Bone is living, growing tissue. It is made mostly of collagen, a protein that provides a soft framework, and calcium phosphate, a mineral that adds strength and hardens the framework. Vitamin D helps the body absorb and process calcium. Together, these two nutrients are the cornerstone of healthy bones.

Osteoporosis, or porous bone, is a disease characterized by low bone mass and structural deterioration of bone tissue, leading to bone fragility and an increased risk of fractures of the hip, spine, and wrist. There are many causes of osteoporosis. Not only do bones lose density with age, medications used to treat breast cancer, arthritis, asthma, Crohn's disease and Addison's disease can also lower bone density. Some illnesses such as hyperthyroidism, hypopituaritism and eating disorders also cause bones to lose strength.

Nutrition: Nutrition, especially calcium, plays an important role in preventing osteoporosis. In people who have healthy bones, adequate calcium intake on a daily basis is necessary to maintain bone health.

Living with the Disease: It is common to feel anxious about health or lifestyle when diagnosed with osteoporosis feelings of loneliness; depression and helplessness are all very common.

Exercises for Healthy Bones: Exercise is recommended for all people with osteoporosis, even people who have had a spine or hip fracture. Exercise is an important step towards protecting the bones, as it helps protect the spine, slows the rate of bone loss, and builds muscle strength, which can prevent falls

Calcium and Vitamin D: Calcium and Vitamin D are essential nutrients for proper bone health. Vitamin D helps to increase the absorption of calcium, ultimately building stronger bones. It also improves the function of muscles, improving your balance and decreasing the likelihood of falls, which can lead to fractures.

Steroid hormone may be a steroid that is a hormone. It is often divided into two groups: corticosteroids and sex steroids. Within these two classes, they're five types consistent with their receptors: glucocorticoids, mineralocorticoids, androgens, estrogen and progestogens. In physical body, steroid hormones play a crucial part in metabolism, inflammation, immune functions, salt and water balance, development of sexual characteristics and therefore the ability of withstanding illness and injury. The natural steroid hormones are generally synthesized from cholesterol within the gonads and adrenal glands. These hormones are lipophilic substance. They will undergo the cell wall as they're fat-soluble, then bind to steroid receptors (which could also be nuclear or cytosolic counting on the steroid hormone) to cause changes within the cell. Steroid hormones are generally carried within the blood, sure to specific carrier proteins like sex hormone-binding globulin, corticosteroid-binding globulin and albumin. The binding is useful to assist improve the hormones’ solubility in water.

Exploring the Endocrine and Diabetic Connection:

Cardiac remodeling refers to structural and functional changes in the heart in response to various stressors, including cardiovascular diseases, hypertension, and diabetes. In particular, the interplay between the endocrine system and diabetes has a profound impact on the heart's structure and function. In this article, we will explore the connection between endocrine factors, especially diabetes, and cardiac remodeling. We will also discuss nutritional strategies that can be employed to mitigate these adverse effects and promote heart health.

The Endocrine System's Role in Cardiac Remodeling:

1. Diabetes and Cardiac Remodeling:

Diabetes, both type 1 and type 2, is a major risk factor for cardiac remodeling. Chronic hyperglycemia, insulin resistance, and inflammation contribute to adverse structural and functional changes in the heart. These changes can lead to conditions such as diabetic cardiomyopathy and heart failure.

2. Hormones and Cardiac Function:

Various hormones, such as insulin, glucagon, and leptin, play crucial roles in regulating heart function. Dysregulation of these hormones, as often seen in diabetes, can result in myocardial dysfunction and remodeling.

Nutritional Strategies to Mitigate Cardiac Remodeling:

1. A Balanced Diet:

2. Omega-3 Fatty Acids

3. Antioxidants

4. Glycemic Control

5. Weight Management

6. Salt Restriction

7. Regular Physical Activity

Cardiac remodeling is a complex process influenced by various factors, including the endocrine system and diabetes. However, through targeted nutritional strategies, it is possible to mitigate the adverse effects on the heart. A heart-healthy diet, along with lifestyle modifications, can play a vital role in preventing and managing cardiac remodeling, ultimately leading to improved cardiovascular health. Further research and clinical studies are essential to refine these nutritional approaches and better understand the intricate connections between the endocrine system, diabetes, and cardiac health.

With a prevalence of about 10% on MR imaging in the general population, Pituitary tumors are more common than typically thought.  At an equivalent time, many endocrinologists and internists might not have sufficient exposure to deal confidently with a spread of pituitary disorders. If not properly treated, pituitary disorders may end in significant morbidity and lower anticipation. The pituitary is that the center of human sexuality and reproduction. Other parts of the body do most of the work but the pituitary initiates and controls the processes. Due to hormones about 30 and 40% of the population suffers sexual dysfunction at a while in their life. Endocrinology Society studies have reported that CDI is more prevalent in children and older adults (>80 years of age). Primary tumors of the pituitary fossa result in CDI in 50% of children and 30% of adults while head trauma to the posterior pituitary gland accounts for 2% of cases in children and 17% in adults. Hypopituitarism is listed as a rare disorder by the National Institutes of health. To date, there are not any US-based studies on the prevalence and incidence of hypopituitarism. One published report indicated it affects but 200,000 individuals within the US. And therefore the 2010 National Hospital Discharge Survey reported 17,101 US inpatient hospital visits with anhypopituitarism/ hypopituitarism) together of any listed diagnoses, and 749 visits with this because the primary diagnosis. Additionally, the reported average hospital stay was 5.4 days.

Transgender is an umbrella term for a diverse group of people such as trans women (male-to-female) and trans men (female-to-male), genderqueer individuals, and many others whose gender identity or expression differs from societal expectations of how they should look, act, or identify based on the sex they were assigned at birth. Transgender and other gender minority people are often the targets of discrimination and harassment that can lead to negative health outcomes. The term “gender nonconforming” is used to describe individuals whose gender identity, role, or expression differs from what is normative for their assigned sex at birth in a given culture and historical period.

Transgender is used as an umbrella term to describe individuals whose gender identity differs from the assigned sex at birth. Transgender males are people assigned female at birth but who self-identify as male. Transgender females are people assigned male at birth, but who self-identify as female. Transgender individuals are often denied insurance coverage for appropriate medical and psychological treatment. Over the last decade, there has been considerable research on and development of evidence-based standards of care that have proven to be both safe and efficacious for the treatment of gender dysphoria/gender incongruence. There is also a growing understanding of the impact that increased access to such treatments can have on the mental health of these individuals.

· Gender identity

· Diagnosis

· Medical Treatment

· Endpoints

· Concerns